Sunday, April 19, 2009

Vigorous Exercise May Help Prevent Vision Loss

Vigorous exercise may help prevent vision loss, according to a pair of studies from the U.S. Department of Energy's Lawrence Berkeley National Laboratory. The studies tracked approximately 31,000 runners for more than seven years, and found that running reduced the risk of both cataracts and age-related macular degeneration.

The research, which is among the first to suggest that vigorous exercise may help prevent vision loss, offers hope for people seeking to fend off the onset of eye disease.
"In addition to obtaining regular eye exams, people can take a more active role in preserving their vision," says Paul Williams, an epidemiologist in Berkeley Lab's Life Sciences Division who conducted the research. "The studies suggest that people can perhaps lessen their risk for cataracts and macular degeneration by taking part in a fitness regimen that includes vigorous exercise."

A cataract, which is a cloudy opacity of the eye lens, is the leading cause of blindness. More than one-half of people in the U.S. over the age of 65 suffer from some form of cataracts. Macular degeneration, which is damage to the retina, is the leading cause of irreversible vision loss in older white Americans, affecting 28 percent of people aged 75 and older.

Macular degeneration gradually destroys sharp, central vision. Macular degeneration affects the macula, the part of the eye that allows you to see fine detail. The macula is located in the center of the retina, the light-sensitive tissue at the back of the eye. The retina instantly converts light, or an image, into electrical impulses. The retina then sends these impulses, or nerve signals, to the brain. Macular degeneration causes no pain.

The diseases have several known risk factors, such as sunlight exposure and diabetes in the case of cataracts, but few interventions. Now, it appears that vigorous cardiovascular exercise may be one way to derail the diseases.

To conduct the research, Williams analyzed data collected in the National Runners' Health Study, which he established in 1991 to determine the health benefits of running.

In this case, he followed approximately 29,000 male runners and 12,000 female runners for more than seven years. Of these people, 733 men reported being diagnosed with cataracts on a questionnaire filled out at the end of the study. Too few women reported cataracts to track.

Men who ran more than 5.7 miles per day had a 35 percent lower risk of developing cataracts than men who ran less than 1.4 miles per day. The study also analyzed men's 10-kilometer race performances, which is a good indicator of overall fitness. The fittest men boasted one-half the risk of developing cataracts compared to the least-fit men.

A second study found that running appeared to reduce the risk of macular degeneration. In the study, 152 men and women reported being diagnosed with the disease. Compared to people who ran less than 1.2 miles per day, people who averaged between 1.2 and 2.4 miles per day had a 19 percent lower risk for the disease, and people who ran more than 2.4 miles per day had between 42 percent and 54 percent lower risk of macular degeneration.

"These findings are compelling because of the large size of the study, and the fact that we are looking at something that is fairly well defined: vigorous exercise, as opposed to more moderate exercise," says Williams.

Most of the runners in the study exceeded the current public health recommendations for physical activity, which is at least 30 minutes of moderate-intensity activities such as brisk walking five days a week, or smaller doses of more vigorous exercise such as running. It is unclear whether people might also lower their risk for cataracts and age-related macular degeneration by walking.

"We know there are important health benefits to walking, including lowering heart disease risk," says Williams. "It is quite likely that the studies' results might apply to a lesser extent to smaller doses of more moderate exercise."

Williams also adds that further research is needed to explore why there is a link between vigorous exercise and a decreased risk for eye disease.

"We know some of the physiological benefits of exercise, and we know about the physiological background of these diseases, so we need to better understand where there's an overlap," says Williams.

Saturday, April 11, 2009

Implantable Eye Telescope Brings Sight Back To The Blind

Implantable Eye Telescope Brings Sight Back To The Blind
Written on April 10, 2009 – 10:45 am | by Drew Halley |

imt_photoFor the millions of people who suffer from age-related eye degeneration, restoring sight to the blind might sound less like reality and more like a miracle. But thanks to an incredible miniature eye implant that works to restore central vision, the future’s looking bright.

The macula is a part of the retina responsible for highly detailed central vision. It contains a high density of cone cells, which allow us to perceive fine detail and quick movement in our environment - for healthy individuals, that is. Patients suffering from age-related macular degeneration (AMD) partially or totally lose this functionality, resulting in a “blind spot” where their focal point normally rests. This can make it difficult to read, recognize faces, or even watch television… until now.

The Implantable Miniature Telescope, or IMT, is a tiny prosthetic implanted into the patient’s eye. Rather than directing light to the damaged macula, the telescope projects the image onto a broader surface of the retina that surrounds the macula. In this way, visual information is redirected to healthy rods and cones, and can be processed in the brain as central vision.

Both central and peripheral vision are important functions of the visual system. Because of this, the IMT is only implanted into one eye of patients with macular degeneration. One eye continues to process peripheral vision normally (which is better suited for low-light vision, for example), while the implanted eye restores the central vision that was previously impaired. This allows individuals to again experience the full range of visual stimuli so necessary to everyday life. And because the implant is embedded in the iris, it goes unnoticed to others.

A simulation of impaired vision caused by AMD

Macular degeneration primarily effects older adults, and is the leading cause of blindness in the elderly. Nearly 15 million people suffer from AMD in the United States alone. Approximately 10% of adults between the ages of 66 and 74 suffer from AMD, a figure that jumps to 30% between the ages of 75 and 85, according to The Eye Digest.

“In an end-stage AMD population, the indicated improvements in this study are substantial compared to risks of surgery,” said study coauthor R. Doyle Stulting, M.D., Ph.D. “For patients with this level of visual impairment, the ability to be less dependent on others and to reclaim even a few of the activities they once enjoyed could make a real difference in their lives.”

The IMT was developed by VisionCare Ophthalmic Technologies, and the implant has recently completed Phase II/III clinical trials. The tests showed that the IMT doubled the vision of 2/3 of participants’ eyes (3 lines on a visual acuity chart) after one year with the implant. Some patients experienced side effects like intraocular pressure and inflammation, though these may have been related to the surgury. On March 27, an advisory panel for the Food and Drug Administration (FDA) unanimously recommended the prosthetic for approval. Barring any unforeseen events, the IMT will soon gain FDA approval and hit the market soon thereafter.

While the IMT is certainly an amazing breakthrough, it is just one of many technologies we’ve reported on that are overcoming blindness (such as bionic eyes and gene therapy). Besides the direct clinical application of such amazing technology, eye implants beg the question of how far these kinds of advances will go. Who knows? Maybe your grandkids will sport bionic eyes capable of zooming, night vision, and infrared perception. Regardless, anatomical prosthetics like the IMT promise to improve individuals’ lives today, and lay the theoretical foundation for exciting technology to come.

Sunday, April 5, 2009

Purdue Professor's Insight Leads to Better Understanding of Vision Loss

Purdue Professor's Insight Leads to Better Understanding of Vision Loss

WEST LAFAYETTE, Ind., April 3 (AScribe Newswire) -- A Purdue University researcher's work could shed light on new targets for treating retinal degenerative diseases that cause blindness.

According to the National Eye Institute, blindness or low vision affects 3.3 million Americans age 40 and older, and retinal degenerative diseases, such as age-related macular degeneration and diabetic retinopathy, are some of the leading causes.

Yuk Fai Leung, an assistant professor of biological sciences, co-led a team that developed a new analysis method and identified key genes involved in retinal development. A paper detailing the work was published in the Proceedings of the National Academy of Sciences last fall.

"Once we know the genetic network that influences retinal development, we can begin to understand the changes in specific genes that lead to vision loss," Leung said. "With this information, treatments could be developed that would prevent or reverse the physical affects."

Leung also recently received a $25,000 award from Hope for Vision, a nonprofit foundation that raises money to develop treatments and cures for diseases that cause blindness.

Leung led the research with John E. Dowling of the Department of Molecular and Cellular Biology at Harvard University. The research team used the analysis method to identify genes that control cellular differentiation in the retina of zebrafish.

Zebrafish are closer to humans in eye development than mice or other animal models, Leung said.

The analysis method, called factorial microarray analysis, can examine thousands of genes at once and analyze several experimental changes at the same time. Examining several changes at once is critical for understanding how one change can lead to several others, Leung said.

"Some important changes could seem insignificant if examined in isolation," he said. "For example, both eating nutritious food and swimming for an hour are good for your health. However, if you eat right before swimming, you will probably get sick. Only by doing both at the same time is the issue identified."

Additional members of the research team and paper co-authors include Ping Ma from the Department of Statistics and Institute for Genomic Biology at the University of Illinois and Brian A. Link from the Department of Cell Biology, Neurobiology and Anatomy at the Medical College of Wisconsin.

The team compared the genetic makeup of normal fish with fish that were blind due to improper development of retinal cells. The cells begin on the same track as those in the normal fish but do not complete the final stage of development known as terminal differentiation.

Leung and his team were able to identify the genetic network that controls the terminal differentiation process and to examine the effects of different combinations of genetic changes at different stages within the developmental process.

"We still don't know a lot about eye development, so we need to gather knowledge to figure out what goes wrong in a disease situation," he said. "We know the genes involved, but don't know much about the downstream changes a mutation causes. This work sets up the framework and model that can be used to examine such cause-and-effect relationships."

Leung plans to study other developments to obtain a more complete picture of eye development.

This research was funded by the Croucher Foundation, Knights Templar Foundation, Merck Award for Genomics Research, National Eye Institute and National Science Foundation.

Monday, March 30, 2009

New Hope for Preventing Age-related MD

By Shahreen Abedin
CNN Senior Medical Producer

(CNN) -- Researchers may be getting closer to an effective way of preventing age-related macular degeneration, one of the leading causes of vision loss among older Americans.
A new study found that vitamins B6, B12 and folic acid may help prevent age-related macular degeneration.

A new study found that vitamins B6, B12 and folic acid may help prevent age-related macular degeneration.

A new study finds that women who took a combination of B6 and B12 vitamins along with a folic acid supplement had lower risks of developing age-related macular degeneration. The women who got the supplements, compared with those taking a placebo, had a 34 percent lower risk of developing any form of AMD, and a 41 percent lower risk of more severe forms of AMD.

Epidemiologist and study author William G. Christen, Sc.D., of Brigham and Women's Hospital and Harvard Medical School, expects that if these findings are successfully replicated in future studies, "the combination of these vitamins might become the first prevention method of early stages of age-related macular degeneration other than avoiding cigarette smoking."

Christen also noted that although the study was conducted among women age 40 and older, there is no particular reason to believe the same results would not hold true in a similar group of men.

Christen and his colleagues examined the role of vitamins B6 and B12 and folic acid in AMD partly because previous studies have shown these vitamins are known to lower levels of homocysteine, an amino acid found in the blood that when elevated has been associated with higher risks of AMD. Visit CNNhealth.com, your connection for better living

The 5,442 women who participated in the randomized, double-blind clinical trial already had heart disease or at least three risk factors for cardiovascular disease. The majority of them did not have AMD at the start of the study, which lasted more than 7 years. Christen explains that the underlying mechanism of AMD likely involves the vascular system, and researchers widely believe that cardiovascular disease and AMD share common risk factors.
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* Smoking quadruples risk for vision-stealing eye disease
* National Eye Institute: Age-Related Macular Degeneration

Age-related macular degeneration is a vision disease common among people older than 60, involving the deterioration of tissues in the macula, the central part of the retina. The condition impedes the performance of critical everyday functions such as reading and driving because it affects the ability to see items that a person is looking at directly, as opposed to items even a few degrees off to either side of the direct line of vision.

"If you affect that central part of your vision, no one goes blind from it but it really interferes with your quality of life," explains Dr. Roy Rubinfeld, ophthalmologist and spokesperson for the American Academy of Ophthalmology.

There are two types of macular degeneration: wet and dry. Wet forms of AMD are caused by abnormal blood vessels growing beneath the macula, which can rupture and bleed. The dry form is generally caused by cells in the macula degenerating over time and thus losing function.

While some treatments do exist for the wet form of the disease (including laser surgery, photodynamic therapy and injections into the eye), there is currently not much in the way of treatments for the more common dry form.
Health Library

When asked if the study results mean that people at high risk for AMD should begin taking a vitamin supplement that provides vitamins B6, B12 and folic acid, retina specialist Dr. Robert Frank of the American Academy of Ophthalmology suggests probably not yet.

"If you do anything, I would take a supplement of antioxidant vitamins containing high doses of vitamins A, E, C and zinc," suggests Frank, who has no financial interest in the vitamin supplement industry. These antioxidant vitamins were found to prevent the progression of age-related macular degeneration in the 10-year Age-Related Eye Disease Study conducted by the National Eye Institute of the National Institutes of Health.

However, Frank does say that while it still remains to be seen whether people currently taking a multivitamin containing the B vitamins and folic acid will be able to prevent early AMD from developing -- answers which will probably not be found for several years, after a large-scale clinical trial is begun -- there is little risk for most people in taking a daily multivitamin.

Saturday, March 21, 2009

Food For The Eyes

Food for the Eyes

Last Update: 3/20 1:19 pm
Source: WXYZ Detroit

Many of us plan our meals around certain foods hoping to keep our bodies healthy, but not many of us think specifically about our eyes. We have a heads up on culinary choices that can help you see better, longer. In fact, these can be called 'food for the eyes!'

Blair Carper, (worried about his vision)
"I used to be able to see things really sharp and now I don't see things as well."

He's heard carrots are good for the eyes and he's right, but they're not the only way to protect your view of the world. A recent study shows several nutrients in supplemental form help slow the progression of serious eye diseases. Ophthalmologist Sunil Srivastava says incorporating even small amounts into your regular diet can only help. One food with benefits-eggs.

Sunil Srivastava, MD, Ophthalmologist, Emory University
"Eggs do have a lot of good vitamins, such as vitamin A. Vitamin A is important in the function of the eye, specifically the retina, so vitamin A deficiencies can actually lead to night blindness."

Then there are raspberries. The vitamin C in them helps reduce the risk of cataract formation. Almonds are up next because they contain vitamin E.

Sunil Srivastava, MD, Ophthalmologist, Emory University
"Vitamin C and vitamin E have been shown to, at elevated levels, reduce the risk of things like macular degeneration in high risk patients."

Salmon or more specifically fish oil, along with green leafy vegetables, also help prevent macular degeneration, an illness that causes blindness. Ten million Americans are already coping with the disease.

Sunil Srivastava, MD, Ophthalmologist, Emory University
"Lutein and zeaxanthin are certain types of pigments that actually are concentrated in the macula of our retina, which is the center part of our vision, and foods like broccoli and spinach have high levels of lutein and zeaxanthin."

Aslo, try yogurt because the zinc in it helps the body absorb antioxidants, which also help the eyes.

Other good sources of vitamin A are cantaloupe, sweet potatoes, and mango.

Saturday, March 14, 2009

Eat Better Foods to Keep Eyes Healthy

March is Save Your Vision Month, sponsored by the American Optometric Association, or AOA. This year's theme is to pay more attention to nutrition to care for your eyes.

The AOA recommends increasing nutrients for healthy eyes, especially for people coping with vision loss or other eye problems.

Cataracts and age-related macular degeneration are the two leading causes of vision loss and blindness. One out of four Americans age 40 and older suffer from some level of vision loss. Patient clinical trials by the National Institutes of Health found age-related macular degeneration to be a nutrition responsive disorder. Multivitamins typically deliver nutrients below the recommended level for eye health.

Having a daily intake of certain nutrients has been linked to healthy eyes and may reduce the risk of some chronic eye conditions. Intake can be either through foods or supplements. Consult your eye health professional or physician before making changes in your diet or supplementation.

Eat foods rich in the following nutrients to help protect your eye sight and vision.

Lutein is found in colorful produce such as green beans, spinach, broccoli, oranges and corn.

Essential fatty acids are found in tuna, salmon, whole grains, lean meats and eggs.

Vitamin C is found in papaya, oranges, green peppers, and tomatoes.

Vitamin E is found in nuts & seeds like almonds, pecans, peanut butter and sunflower seeds, also sweet potatoes.

Zinc is found in whole grains, baked beans, poultry, shellfish, milk and red meat.
Renee Veksler is a Guam Memorial Hospital health educator and community partner with the Get Healthy Guam Coalition. Contact her at 647-2351.

Saturday, March 7, 2009

Top Ten Healthy Things to Do for Your Eyes

Top Ten Healthy Things to Do for Your Eyes
A Guide to Protecting Your Eye Health Every Day
Jennifer Palombi

Mar 5, 2009
Controlling risk for eye disease and protecting your eyes daily is important to keep your world in focus.

How often do you have your eyes examined?

Doctors agree that people should follow a consistent regimen of annual eye exams to prevent potentially serious eye complications. But what can you do the rest of the year to insure healthy eyes? This is, after all, the only pair of eyes you’ll get so they’re worth taking care of.

With that in mind, here are the top ten healthy things that you can do for your eyes:

1. See Your Eye Doctor Annually

Medical experts urge all patients with diabetes to have dilated eye exams once per year. Pupil dilation allows your doctor to see more of the inside of your eye in order to thoroughly check for signs of disease. Yet in a study performed just a few years ago, 35 percent of people had not had a dilated exam in the previous year.

2. Get Yourself a Good Pair of Sunglasses

UV radiation is harmful to the eyes and can cause cataracts. Sunglasses with broad spectrum UVA/UVB protection can help prevent harmful radiation from entering and damaging the eyes. Check with your local optical shop for a good pair of UV protective lenses. Then wear your sunglasses year round – UV radiation on the ski slopes is just as harmful as UV radiation on your favorite stretch of beach.

3. Wear Safety Glasses When the Occasion Calls For It

Whether you’re trimming shrubs in your back yard, woodworking in your garage or finally getting around to those home improvements you’ve been considering, your eyes are at risk for serious injury from flying debris. Protective glasses with polycarbonate lenses dramatically reduce the risk of eye injury associated with many of our favorite hobbies.

4. Eat Your Veggies

Your mom was right. Studies have shown that the antioxidants found in green leafy vegetables are beneficial in reducing your risk for eye diseases such as macular degeneration.

5. Control Your Blood Sugar

Stable blood-glucose levels over prolonged periods are an important factor in reducing your chance of developing a serious condition known as diabetic retinopathy. Retinopathy occurs when the blood vessels of the retina become leaky or blocked. It occurs more often in cases of poorly controlled blood glucose and can lead to severe vision loss.

6. Watch That Blood Pressure

People who suffer from hypertension can develop hypertensive retinopathy among other eye complications. By simply controlling your blood pressure, you can dramatically reduce your chances of developing eye problems.

7. Learn About All of Your Medicines

Did you know that steroid anti-inflammatory drugs (such as prednisone) can cause cataracts? Or that some drugs can cause dry eyes and still others can increase your risk for glaucoma? Know the potential complications of your medicines and be sure to report all prescription drugs and dosages to your eye doctor at each and every eye exam.

8. Wear Your Contacts as Directed

Wearing disposable lenses too long or sleeping with contacts not designed for extended-wear can put you at risk for developing vision-threatening infections. Dispose of your lenses at the prescribed interval and don’t sleep with contact lenses unless your eye doctor expressly gives you permission to do so. Most people who wear extended-wear contacts should see their eye doctors every 6 months to evaluate the health of their corneas.

9. Know Your Family History

Some eye diseases, such as macular degeneration, glaucoma and certain forms of corneal disease have a genetic link. If you have blood relatives with these conditions, you could be at higher risk for developing them yourself. Familiarize yourself with your family’s eye health history and let your eye doctor know when any new conditions develop.

10. Educate yourself!

The eyes are more than windows to the soul—they’re your windows to the world. Be mindful each day of taking these simple steps to help keep your world in focus.

For more information on eye health or to find an eye doctor in your area, contact the American Optometric Association, the American Academy of Ophthalmology at www.aao.org, or check out Prevent Blindness America’s information page.


The copyright of the article Top Ten Healthy Things to Do for Your Eyes in Patient Health Education is owned by Jennifer Palombi. Permission to republish Top Ten Healthy Things to Do for Your Eyes in print or online must be granted by the author in writing.


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